The Arrizabalaga Lab

Our Publications

Yang, C., and Arrizabalaga, G., 2017. The Serine/Threonine Phosphatases of Apicomplexan Parasites. Molecular Microbiology

LaFavers, K.A, Márquez-Nogueras, K.M., Coppens, I., Moreno, SNJ, Arrizabalaga, G. A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii. Cell Microb, PMID: 28430089. Read it!

Colinot, D.L., Garbuz, T., Bosland, M., Rice, S., Wang, L., Sullivan, W.J., *Jerde, T. *Arrizabalaga, G., 2017 Toxoplasma gondii: a novel inducer of chronic prostatic inflammation and proliferative inflammatory microglandular hyperplasia in a mouse model of prostatic inflammation. Prostate, PMID: 28497488. *Senior authors contributed equally. Read it!

Padgett, L., *Sullivan, W.J., *Arrizabalaga, G., 2016, Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii. Traffic. 2017 Mar;18(3):149-158. PMID:27991712 *Senior authors contributed equally Read it!

Charvat, R. and Arrizabalaga, G., 2016. Oxidative stress generated during monensin treatment contributes to altered Toxoplasma gondii mitochondrial function. Nature Scientific Reports, 2016 Mar 15;6:22997.  Read it!

Varberg, J.M., Padgett, L.R., Arrizabalaga, G., Sullivan, W.J., 2016. TgATAT-mediated α-tubulin acetylation is required for division of the protozoan parasite Toxoplasma gondii. mSphere, Jan 20;1(1). pii: e00088-15. Read it!

 

Gaji, R. Johnson, D., Wang, M., Hudmon, A., and Arrizabalaga, G., 2015. Phosphorylation of a Myosin motor by TgCDPK3 facilitates rapid initiation of motility during Toxoplasma gondii egress. PLoS Pathog. 1(11):e1005268. PMID: 26544049 Read it!

 

Benmerzouga, I., Checkley, L., Ferdig, M., Arrizabalaga, G., Wek, R., and Sullivan, W., 2015. Guanabenz repurposed as an anti-parasitic with activity against acute and latent toxoplasmosis, Antimicrob Agents Chemother, 59(11):6939-45. PMID: 26303803  Read it!

 

Treeck, M., Sanders, J., Gaji, R., LaFavers, K., Child, M., Arrizabalaga, G., Elias, J., Boothroyd, J., 2014 The calcium-dependent protein kinase 3 of Toxoplasma influences basal calcium levels and functions beyond egress as revealed by quantitative phosphoproteome analysis. PLoS Pathogen, 10(6):e1004197. Read it!

 

Campodonico J, Kochhar K., , Arrizabalaga G, and Sevilla-Martir, 2015 Assessing knowledge and perceptions related to preventive methods and treatment of malaria in the local endemic area of Trujillo, Honduras. Hispanic HealthCare International Journal, 13(2):97-108

 

Gaji, R., Checkley, L., Reese, M., Ferdig, M.T., and Arrizabalaga, G., 2014,  Expression of the essential kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother, 58(5):2598-607. Read it!

 

I. J. Blader, G. Arrizabalaga, and W. J. Sullivan. The Role of Host- And Parasite-Encoded Kinases in Toxoplasma-Host Interactions.” Invited Chapter Review for “Protein Phosphorylation in Eukaryotic Parasites: Potential for Chemotherapy”. Edited by Christian Doerig, Gerald Spaeth, Martin Wiese, and Paul Selzer. 2013.

 

Garrison, E., Treeck, M., Ehret, M., Garbuz, T., Oswald, B.P., Settles, M., Boothroyd, J., Arrizabalaga, G., 2012, A forward genetic screen reveals calcium-dependent kinase 3 is critical for calcium-induced egress in Toxoplasma. Plos Pathogen, 8(11).  Read it!

 

Lavine, M.D. and Arrizabalaga, G., 2012, Analysis of Monensin Sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death. Plos One, 7(7):e42107. Read it!

 

Hass, J., Garrison, E., Wicher, S., Knapp, B., Bridges N., McIlroy, D. and Arrizabalaga, G., 2012. Synthetic osteogenic extracellular matrix formed by coated silicon dioxide nanosprings. Journal of Bionanotechnology, 10 (6),.  Read it!

 

Kamau E., Meehan T., Lavine M.D., Arrizabalaga, G., Mustata, G. and Boyle, J. 2011. A novel benzodioxole-containing inhibitors of Toxoplasma gondii growth alters the parasite cell cycle. Antimicrob Agents Chemother, 55(2): 745-55.  Read it!

 

Francia, M.E., Wicher S., Pace D.A., Sullivan, J., Moreno, S.N.J., and Arrizabalaga, G., 2011. A Toxoplasma protein with homology to intracellular type Sodium Hydrogen Exchangers is required for osmotolerance and protein processing. Experimental Cell Research. 317(10):1384-96.  Read it!

 

Lavine, M.D. and Arrizabalaga, G., 2011. The antibiotic monensin causes cell cycle disruption of Toxoplasma gondii, mediated through the DNA repair enzyme TgMSH-1. Antimicrob Agents Chemother, 55(2): 745-55.  Read it!

 

Arrizabalaga G.,  2011. A fine balance between life and death: modulation of BCL-2 family members by Toxoplasma gondii. Frontier in Cellular and Infection Microbiology. 2:39

 

Garrison, E. and Arrizabalaga, G., 2009. Disruption of a mitochondrial homolog of a MutS DNA Repair Enzyme confers drug resistance in the pathogenic parasite Toxoplasma gondii. Molecular Microbiology, 72(2):425-41.  Read it!

 

Lavine, M.D. and Arrizabalaga, G., 2009. Induction of mitotic S-phase of host and neighboring cells by Toxoplasma gondii enhances parasite invasion. Molecular and Biochemical Parasitology, 164(1):95-9. Read it!

 

Saeij, J., Arrizabalaga, G. and Boothroyd J.C. 2008. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. 2008 Immunity and infection, 76(6):2402-10. Read it!

 

Lavine, M and Arrizabalaga, G., 2008 Exit from host cells by the pathogenic parasite Toxoplasma gondii does not require motility. Eukaryotic Cell, 7(1): 131-140.  Read it!

 

Fruth, I.A. and Arrizabalaga G., 2007.  Toxoplasma gondii: Induction of egress by the potassium ionophore nigericin. International Journal of Parasitology, International Journal of Parasitology, 37(14): 1559-67.  Read it!

 

Lavine, M.D., Knoll, L.J., Rooney, P.J. and Arrizabalaga, G., 2007. A Toxoplasma gondii mutant defective in responding to calcium fluxes shows reduced in vivo pathogenicity. Molecular and Biochemical Parasitology,155(2): 113-122.  Read it!

 

Lavine, M.D., and Arrizabalaga, G., 2007. Invasion and egress by the obligate intracellular parasite Toxoplasma gondii: potential targets for the development of new antiparasitic drugs. Current Pharmaceutical Design. 13, 641-651. Read it!

 

Saeij, J. P. J., Boyle, J. P., Grigg, M.E., Arrizabalaga G., and Boothroyd J. C. 2005. Bioluminescence imaging of Toxoplasma infection in living mice reveals dramatic differences between strains. Infect Immun 73(2); 695-702.  Read it!

 

Karasov, A, Boothroyd J.C. and Arrizabalaga, G., 2005. Identification and disruption of a rhoptry localized Sodium Hydrogen Exchanger in Toxoplasma gondii.  International Journal of Parasitology, 35 (3); 285-291.  Read it!

 

Arrizabalaga, G., Ruiz, F., Moreno, S. and Boothroyd J.C., 2004. Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation. Journal of Cell Biology: 165(5):653-62,. Read it!

 

Arrizabalaga, G., Boothroyd J.C., 2004. Role of calcium during invasion and egress in Toxoplasma gondii. International Journal of Parasitology 34; 361-368. Read it!

 

Camps, M., Arrizabalaga, G. and Boothroyd J.C., 2002. An rRNA mutation identifies the apiclopast as the target for clindamycin in Toxoplasma gondii.  Molecular Microbiology 43(5):1309-18. PMID: 11918815. Read it!

 

Black, M.W., Arrizabalaga, G. and Boothroyd J.C., 2000. Ionophore-resistant mutants of Toxoplasma gondii reveal host-cell permeabilization as an early event in egress. Mol. Cell Bio. 20; 9399-9408. Read it!

 

Arrizabalaga, G. and Lehmann, R., 1999.  A selective screen reveals discrete functional domains in Drosophila Nanos.  Genetics 153; 1825-1838. Read it!

 

 

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